Cytogenetic abnormalities in 200 male infertile cases in the southern region of India
نویسندگان
چکیده
Chromosomal abnormalities are one of the major causes of male infertility. But the exact mechanism by which chromosomal anomalies induces infertility is still not clear. Many studies have documented the chromosomal abnormalities ranging from 2.2% to 15.7% in infertile men. The present study has been carried out to document and find out the genetic cause of male infertility in the Southern region of India. The cytogenetic analysis of 200 male infertile cases, referred due to primary infertility from 2009 to 2012, were analyzed by GTG banding and evaluated retrospectively. The semen analysis was also performed. A total of 15 cases (7.5%) showed chromosomal aberrations. Four (2%) were 47, XXY and mosaic 47,XXY; Two (1%) were structural autosomal abnormalities; Two (1%) were inversion Y; Seven (3.5%) cases were Y heterochromatin variants and 185 cases (92.5%) showed normal 46,XY karyotype. The chromosomal abnormalities in our study is also in agreement with the data from the literature. Also abnormal spermatogenesis is observed in these cases. Apart from chromosomal analysis further in depth molecular analysis and genetic counseling is suggestive in such cases, especially those interested in IVF technologies.
منابع مشابه
Cytogenetic Analysis in Infertile Male Patients with Oligospermia and Azoospermia in the Southern Region of Iran, Shiraz
Infertility, considered as one of the main public health issues, affects about 10%-15% of the couples in reproductive age. Male factors are known to be responsible for 50% of all infertilities. It is well-established that the chromosomal abnormality is more prevalent in infertile men than in fertile men [1]. In developed countries, the incidence factor is considered to be less, when compared to...
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تاریخ انتشار 2013